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Idiopathic slow‐transit constipation: whole gut transit times, measured by a new simplified method, are not shortened by opioid antagonists
Author(s) -
FOTHERBY K. J.,
HUNTER J. O.
Publication year - 1987
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1987.tb00633.x
Subject(s) - medicine , constipation , gastrointestinal transit , transit (satellite) , transit time , (+) naloxone , mean transit time , opioid , gastroenterology , anesthesia , receptor , political science , transport engineering , law , public transport , perfusion scanning , perfusion , engineering
SUMMARY A simplified method for measuring mean whole gut transit time has been validated which avoids stool collection and is suitable for out‐patients. Radio‐opaque markers are swallowed daily for 14 days and the mean whole gut transit time is derived directly from an abdominal X‐ray. Using this new technique, neither nalmefene (in a double‐blind study of six patients) nor naloxone (in an open study of four patients) shortened mean whole gut transit time in idiopathic slow‐transit constipation.