Premium
The effect of oral cisapride on colonic transit
Author(s) -
KREVSKY B.,
MALMUD L. S.,
MAURER A. H.,
SOMERS M. B.,
SIEGEL J. A.,
FISHER R. S.
Publication year - 1987
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1987.tb00629.x
Subject(s) - cisapride , medicine , transverse colon , gastroenterology , placebo , prokinetic agent , ascending colon , constipation , antiemetic , oral administration , vomiting , pathology , alternative medicine
SUMMARY A prospective double‐blind cross‐over trial of oral cisapride 10 mg and placebo was performed to determine the effects of cisapride on the transit of colonic contents in normal humans. Six male volunteers were studied twice using Colonic transit scintigraphy. After passing a tube to the caecum, 50 μCi of 111 Indium diethylene triamine pentaacetic acid were instilled into the bowel lumen. The movement of radiolabelled material was followed using a gamma camera interfaced to a digital computer. Cisapride decreased the half‐emptying of the caecum and ascending colon from 1.68 ± 0±4 hours to 0.72 ± 0.15 hours ( P < 0.05). The total colon half‐emptying time was reduced from 38.5 ± 7.2 hours to 11.1 ± 2.9 hours on cisapride ( P < 0.05). Cisapride accelerated transit through the transverse colon, but not the descending colon. The progression of the geometric centre was faster during cisapride administration than with placebo ( P < 0.05). The number of bowel movements 48‐hours −1 increased after cisapride from 2.5 ± 0.8 to 5.0 ± 0.4 ( P < 0.05). This study demonstrates that cisapride has a marked prokinetic effect on Colonic transit in normal subjects. Cisapride may be a useful agent in the treatment of constipation.