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Evaluation of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet in patients with inflammatory bowel disease
Author(s) -
HARDY J. G.,
HEALEY J. N. C.,
REYNOLDS J. R.
Publication year - 1987
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1987.tb00627.x
Subject(s) - aminosalicylic acid , medicine , gastroenterology , ulcerative colitis , gastric emptying , inflammatory bowel disease , ileostomy , mesalazine , ileum , terminal ileum , stomach , disease
SUMMARY Gastrointestinal transit of an enteric coated delayed release 5‐aminosalicylic acid tablet radiolabelled with III indium has been monitored in a total of 13 patients with Crohn's disease and ulcerative colitis. More than 70% of the tablets disintegrated in the small intestine, on average 3.2 hours after emptying from the stomach. Dispersed preparation was detected in the proximal colon of all the patients, except one with an ileostomy. Mean peak plasma concentrations of 5‐aminosalicylic acid and its metabolite acetyl‐5‐aminosalicylic acid occurred 3–4 hours after gastric emptying. The tablets provide a reliable means of drug delivery to the ileum and proximal colon.