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Twenty‐four‐hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia
Author(s) -
LANZONMILLER S.,
POUNDER R. E.,
HAMILTON M. R.,
CHRONOS N. A. F.,
BALL S.,
MERCIECA J. E.,
OLAUSSON M.,
CEDERBERG C.
Publication year - 1987
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1987.tb00622.x
Subject(s) - pernicious anaemia , medicine , gastrin , gastroenterology , duodenal ulcer , plasma levels , stomach , endocrinology , secretion
SUMMARY Twenty‐four‐hour intragastric acidity and plasma gastrin concentration were measured in healthy subjects ( n = 16), and patients with duodenal ( n = 12) or gastric ( n = 10) ulceration, or pernicious anaemia ( n = 8). Median integrated 24‐hour intragastric acidity was highest in duodenal ulcer patients and lowest in pernicious anaemia patients (1148 and 0 mmol. hour litre −1 , respectively). Median integrated 24‐hour plasma gastrin was highest in pernicious anaemia and lowest in the healthy subjects (9886 and 238 pmol. hour litre −1 , respectively). Pernicious anaemia patients have unremitting hypergastrinaemia throughout the 24 hours. The results of this study not only provide a reference range of acidity and plasma gastrin in health and disease, but also will act as a baseline for future studies using antisecretory drugs.