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Adverse reactions to sulphasalazine and 5‐amino salicylic acid in the same patient
Author(s) -
BURKE D. A.,
MANNING A. P.,
WILLIAMSON J. M. S.,
AXON A. T. R.
Publication year - 1987
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1987.tb00619.x
Subject(s) - salicylic acid , medicine , sulfasalazine , dermatology , adverse effect , hepatitis , gastroenterology , ulcerative colitis , chemistry , biochemistry , disease
SUMMARY We report a patient who developed sulphasalazine‐related hepatitis with a subsequent adverse reaction to rectal 5‐amino salicylic acid, in the form of pain and fever without associated liver dysfunction, suggesting reactions to both components of sulphasalazine. Included is a review of the literature. Caution should be observed when prescribing 5‐amino salicylic acid to sulphasalazine‐intolerant patients.