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Association of alcohol dehydrogenase polymorphisms and life‐style factors with excessive alcohol intake within the S panish population ( EPIC ‐ S pain)
Author(s) -
Muñoz Xavier,
Amiano Pilar,
Celorrio David,
Dorronsoro Miren,
Sánchez MaríaJosé,
Huerta José M.,
Barricarte Aurelio,
Arriola Larraitz,
Navarro Carmen,
MolinaMontes Esther,
Chirlaque M. Dolores,
Ardanaz Eva,
Rodriguez Laudina,
Duell Eric J.,
Hijona Elizabeth,
HerrerosVillanueva Marta,
Sala Núria,
Bujanda Luis
Publication year - 2012
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2012.03970.x
Subject(s) - adh1b , european prospective investigation into cancer and nutrition , odds ratio , medicine , single nucleotide polymorphism , confidence interval , alcohol dehydrogenase , alcohol , population , prospective cohort study , cohort , aldh2 , demography , physiology , genetics , environmental health , biology , genotype , gene , branched chain alpha keto acid dehydrogenase complex , biochemistry , sociology , dehydrogenase , enzyme
Aims To analyse associations between alcohol dehydrogenase ( ADH ) polymorphisms and alcohol intake in Spanish men and women. Design and settings We analysed the relationship between 21 genetic variants in ADH genes and excessive alcohol intake in both men and women. Single nucleotide polymorphisms ( SNP s) were genotyped using a customized array and a sex‐stratified analysis was performed. Measurements Ethanol intake was calculated using a validated dietary history questionnaire. Participants Heavy consumers of alcohol (≥70 g /day in men, ≥42 g/day in women) (653 cases) and very low or non‐consumers (<2 g /day) (880 controls) from the S panish cohort of the E uropean P rospective I nvestigation into C ancer ( EPIC ). Findings We found statistically significant associations between alcohol intake and known life‐style factors; namely, smoking and food energy intake (meat and fruit/seeds) in both men and women, as well as with physical activity in women and educational level in men. Additionally, we found that a non‐synonymous coding SNP in ADH 1 B (rs1229984) is associated inversely with excessive alcohol intake in men [odds ratio ( OR ) = 0.19, 95% confidence interval ( CI ) = 0.11–0.33; P = 4.77E −10 ) and women ( OR = 0.48, 95% CI = 0.27–0.83; P = 0.0067). Furthermore, ADH 6 rs 3857224 was found associated with heavy alcohol intake in women ( OR = 1.61, 95% CI = 1.21–2.14; P = 1.01E −3 ), but not in men. Conclusions I n the Spanish population, the single nucleotide polymorphism of alcohol dehydrogenase ADH 1 B , rs 1229984, is associated inversely with alcohol intake in both men and women. Another polymorphism of ADH 6, rs 3857224, is associated with heavy alcohol intake in women.