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Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence
Author(s) -
SobczykKopciol Agnieszka,
Broda Grazyna,
Wojnar Marcin,
Kurjata Pawel,
Jakubczyk Andrzej,
Klimkiewicz Anna,
Ploski Rafal
Publication year - 2011
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2010.03248.x
Subject(s) - odds ratio , confidence interval , medicine , obesity , demography , body mass index , alcohol , logistic regression , population , overweight , cross sectional study , risk factor , environmental health , chemistry , biochemistry , pathology , sociology
Aims To investigate whether the FTO rs9939609 A allele (a risk factor for obesity) is associated with measures of alcohol consumption. Design Population‐based cross‐sectional study and two case–control studies. Setting Poland and the Warsaw area. Participants A total of 6584 subjects from the WOBASZ survey and two cohorts of alcohol‐dependent patients ( n = 145 and n = 148). Measurements Questionnaire data analysis, rs9939609 typing. Findings Among individuals drinking alcohol, the obesity‐associated AA genotype was also associated with lower total ethanol consumption [sex‐, age‐ and body mass index (BMI)‐adjusted difference: 0.21 g/day, P = 0.012] and distinct drinking habits with relatively low frequency of drinks but larger volume consumed at a time as evidenced by (i) association between AA and frequency/amount of typical drinks ( P = 0.023, multiple logistic regression analysis); (ii) inverse correlation between AA and drink frequency adjusted for drink size ( P = 0.007 for distilled spirits, P = 0.018 for beer); (iii) decreased frequency of AA [odds ratio (OR) = 0.46, P = 0.0004] among those who drank small amounts of distilled spirits (≤100 ml at a time) but frequently (≥1–2 times/week). A decrease of AA was also found in both cohorts of alcohol‐dependent patients versus geographically matched subjects from WOBASZ yielding a pooled estimate of OR = 0.59, confidence interval (CI): 0.40–0.88, P = 0.008. Exploratory analysis showed that those with rs9939609 AA reported lower (by 1.22) mean number of cigarettes/day during a year of most intense smoking ( P = 0.003) and were older at start of smoking by 0.44 years ( P = 0.016). Conclusions The FTO AA genotype, independently from its effect on BMI, is associated with measures of ethanol consumption and possibly tobacco smoking.