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Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
Author(s) -
Hatsukami Dorothy K.,
Kotlyar Michael,
Hertsgaard Louise A.,
Zhang Yan,
Carmella Steven G.,
Jensen Joni A.,
Allen Sharon S.,
Shields Peter G.,
Murphy Sharon E.,
Stepanov Irina,
Hecht Stephen S.
Publication year - 2010
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2009.02780.x
Subject(s) - nicotine , toxicant , abstinence , lozenge , smoking cessation , medicine , nicotine dependence , tobacco product , physiology , pharmacology , psychiatry , environmental health , toxicity , archaeology , pathology , history
Aims To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence. Design Randomized, parallel arm, semi‐blinded study. Setting University of Minnesota Tobacco Use Research Center. Interventions Six weeks of: (i) 0.05 mg nicotine yield cigarettes; (ii) 0.3 mg nicotine yield cigarettes; or (iii) 4 mg nicotine lozenge; 6 weeks of follow‐up. Measurements Compensatory smoking behavior, biomarkers of exposure, tobacco dependence, tobacco withdrawal and abstinence rate. Findings Unlike the 0.3 mg cigarettes, 0.05 mg cigarettes were not associated with compensatory smoking behaviors. Furthermore, the 0.05 mg cigarettes and nicotine lozenge were associated with reduced carcinogen exposure, nicotine dependence and product withdrawal scores. The 0.05 mg cigarette was associated with greater relief of withdrawal from usual brand cigarettes than the nicotine lozenge. The 0.05 mg cigarette led to a significantly higher rate of cessation than the 0.3 mg cigarette and a similar rate as nicotine lozenge. Conclusion The 0.05 mg nicotine yield cigarettes may be a tobacco product that can facilitate cessation; however, future research is clearly needed to support these preliminary findings.