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Reduced affective symptoms during tobacco dependence treatment with varenicline
Author(s) -
Grosshans Martin,
Mutschler Jochen,
Hermann Derik,
Mann Karl,
Diehl Alexander
Publication year - 2009
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2009.02537.x
Subject(s) - varenicline , exacerbation , smoking cessation , partial agonist , nicotine , medicine , psychiatry , depression (economics) , nicotine dependence , addiction , nicotinic agonist , agonist , psychology , receptor , pathology , economics , macroeconomics
Background The nicotinic acetylcholine receptor partial agonist varenicline has been shown to be effective in the treatment of tobacco dependence, but has been reported to induce exacerbations of psychiatric symptoms in subjects with pre‐existing psychiatric disorders. Case description We report a tobacco‐dependent patient who developed depression and suicidal tendencies during several cessation attempts, but was finally able to stay nicotine‐abstinent by taking varenicline. Conclusion In this case varenicline did not lead to exacerbation but appeared to improve the affective symptoms.