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Varenicline in the routine treatment of tobacco dependence: a pre–post comparison with nicotine replacement therapy and an evaluation in those with mental illness
Author(s) -
Stapleton John A.,
Watson Lucy,
Spirling Lucy I.,
Smith Robert,
Milbrandt Andrea,
Ratcliffe Marina,
Sutherland Gay
Publication year - 2008
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2007.02083.x
Subject(s) - varenicline , nicotine replacement therapy , medicine , smoking cessation , abstinence , mental illness , adverse effect , psychiatry , craving , nicotine , mental health , addiction , pathology
Aims To compare the effectiveness of varenicline with nicotine replacement for smoking cessation and to evaluate the safety and effectiveness of varenicline in people with mental illness. Design Evaluation of consecutive routine cases before and after the introduction of varenicline. Setting National Health Service (NHS) tobacco dependence clinic in London, UK. Participants A total of 412 cases receiving routine care. Intervention Seven group support sessions over 6 weeks with either nicotine replacement therapy (NRT) ( n = 204) or varenicline ( n = 208). Measurements Verified abstinence 4 weeks after quit day, severity of withdrawal symptoms, incidence and severity of adverse drug symptoms, cost per patient treated and cost per successful short‐term quitter. Findings Short‐term cessation rates were higher with varenicline than NRT (odds ratio = 1.70, 95% confidence interval = 1.09–2.67). Varenicline was equally effective in those with and without mental illness. Craving to smoke, but not adverse mood, was less severe with varenicline than NRT. The cost per quitter was similar for varenicline and NRT. There was a higher incidence of adverse drug symptoms among those taking varenicline, but these were tolerated by most smokers. There was no evidence that varenicline exacerbated mental illness. Conclusions In this setting and with group support varenicline appears to improve success rates over those achieved with NRT, and is equally effective and safe in those with and without a mental illness.