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Buprenorphine‐associated gastroparesis during in‐patient heroin detoxification
Author(s) -
Jakobovits Simon L.,
Mcdonough Michael,
Chen Robert Y.
Publication year - 2007
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2006.01684.x
Subject(s) - buprenorphine , gastroparesis , detoxification (alternative medicine) , medicine , gastric emptying , opiate , agonist , heroin , anesthesia , stomach , methadone , gastroenterology , pharmacology , drug , receptor , opioid , alternative medicine , pathology
Background Buprenorphine is a partial mu receptor agonist used in opiate detoxification. It has been shown to cause delayed gastric emptying in healthy volunteers. Case description We describe a case of clinically severe gastroparesis (delayed gastric emptying due to impaired contraction of the stomach) whose onset coincided with the commencement of buprenorphine‐assisted detoxification. Conclusion We review the literature on gastric effects of buprenorphine in healthy volunteers, providing proof of the concept that this was the most probable cause of this patient's gastroparesis.