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Acute effects of cocaine in two models of inhibitory control: implications of non‐linear dose effects
Author(s) -
Fillmore Mark T.,
Rush Craig R.,
Hays Lon
Publication year - 2006
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/j.1360-0443.2006.01522.x
Subject(s) - inhibitory control , inhibitory postsynaptic potential , pharmacology , medicine , psychology , psychiatry , cognition
Aims This study examined dose–response effects of oral cocaine on the inhibitory control of behavior in adult cocaine users using two different behavioral models of inhibitory control. Design Adults ( n = 12) with a history of cocaine use performed the stop‐signal and cue‐dependent go–no‐go task to measure inhibitory control of behavior in response to a range of oral cocaine HCl doses (0, 100, 200 and 300 mg). Findings Although both tasks showed cocaine‐induced facilitation of inhibitory control, dose–response functions differed depending on the measures. The stop‐signal measure revealed a quadratic dose–response function and the cued go–no‐go measure showed a more orderly, linear improvement as a function of dose. Conclusions The evidence suggests a two‐phasic dose–response in which facilitating effects of stimulant drugs on inhibitory control might be limited to a range of intermediate doses, above which improvement is no longer evident and impairing effects could possibly emerge.