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Alprazolam Versus Chlormethiazolc in Acute Alcohol Withdrawal
Author(s) -
TUBRIDY P.
Publication year - 1988
Publication title -
british journal of addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0952-0481
DOI - 10.1111/j.1360-0443.1988.tb02578.x
Subject(s) - alprazolam , medicine , anesthesia , diazepam , carbamazepine , regimen , psychiatry , anxiety , epilepsy
Summary In this 7‐day, double‐blind, parallel‐group study of patients undergoing acute alcohol withdrawal, alprazolam and chlonnethiazole were equally effective as rated by both patients and physician. The starting doses were alprazolam 4 mg/day and chlormethiazole base 3.072 g/day (equivalent to 8g of the edisylate) and a specific tapered dosage regimen teas adhered to. Patients received study medication on days 1‐S; no study medication was given on days 6 and 7. Of the 102 patients who participated in the study, 90 were considered evaluable for efficacy; all available data were included in safety analyses. There was some evidence that alprazolam produced a faster response and was more effective than cklormethiasole in controlling tremor. One patient, in the chlormethiazole group, withdrew from the study early because of side effects (allergic reaction). One alprazolam‐treaced patient had a generalized seizure on day 3 that required treatment with diazepam and carbamazepine, but the patient remained in and completed the study.