Premium
Platelet Monamine Receptor Binding in Alcoholics During Withdrawal
Author(s) -
NUTT DAVID,
GLUE PAUL,
STEWART ANNE
Publication year - 1987
Publication title -
british journal of addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0952-0481
DOI - 10.1111/j.1360-0443.1987.tb00423.x
Subject(s) - monoamine neurotransmitter , platelet , yohimbine , receptor , imipramine , medicine , platelet aggregation , endocrinology , alcohol , serotonin , chemistry , biochemistry , antagonist , alternative medicine , pathology
Summary The binding of 3H‐yohimbine (a measure of alpha‐2‐adrenoceptors) and 3H‐imipramine (a measure of the SHT transporter site) was assessed in whole platelets in a group of 12 recently detoxified male alcoholics. Comparison with age‐ and sex‐ matched control group revealed no differences in either binding capacity (B max) or affinity (Kd) for either ligand. These results suggest that platelet monoamine receptors may not be altered by alcohol or the experience of withdrawal. They are discussed in the light of reported alterations in brain monoamines in alcoholics.