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The Haemolysis Resistance Test (HRT) in Chronic Excessive Drinkers: A Pilot Study
Author(s) -
Negrete J. C.,
Hosein E. A.,
Lee H.,
Goehlert U.
Publication year - 1985
Publication title -
british journal of addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0952-0481
DOI - 10.1111/j.1360-0443.1985.tb05293.x
Subject(s) - haemolysis , abstinence , medicine , ethanol , alcoholic liver disease , alcohol , erythrocyte fragility , chronic alcoholic , gastroenterology , physiology , endocrinology , chemistry , immunology , cirrhosis , hemolysis , biochemistry , psychiatry
Summary A detailed description is given of an assay to test osmotic fragility of erythrocytes in the absence and presence of ethanol (HRT). Samples from alcohol treated rats, and from alcoholic human subjects, showed fragility curves which responded to ethanol in vitro significantly differently when compared to their respective controls. The results with human samples appear to be independent of age, sex, recent abstinence from ethanol, degree of liver dysfunction, and serum cholesterol levels. At this pilot study, the HRT shows a positive predictive accuracy of 76.2 per cent and a negative one of 73 per cent.