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Plasma Nicotine Concentrations from Repeated Doses of Nasal Nicotine Solution
Author(s) -
West Robert J.,
Jarvis Martin J.,
Russell Michael A. H.,
Feyerabend Colin
Publication year - 1984
Publication title -
british journal of addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0952-0481
DOI - 10.1111/j.1360-0443.1984.tb03894.x
Subject(s) - nicotine , chewing gum , nicotine gum , anesthesia , pharmacology , medicine , smoking cessation , plasma levels , chemistry , food science , alternative medicine , pathology , placebo
Summary A nasal nicotine solution (NNS) has been proposed as a potential cessation aid for cigarette smokers [1], the principle being similar to that underlying use of nicotine chewing gum, i.e. nicotine replacement following cessation to ease withdrawal symptoms. We conducted a study to determine the plasma nicotine concentrations resulting from eight, hourly administrations of 2 mg NNS. The peak plasma nicotine concentrations rose to an average of 16.3 ng/ml, which is higher than is normally obtained from 2 mg nicotine chewing gum. There was considerable variability in levels obtained from the NNS, with one subject obtaining levels similar to those found in heavy cigarette smokers. The initial doses produced noticeable light headedness in four of the five subjects. Nasal nicotine solution could provide more effective nicotine replacement than nicotine gum.