Open AccessGenetic alterations in systemic nodal and extranodal non‐cutaneous lymphomas derived from mature T cells and natural killer cells
Author(s) -
Boi Michela,
Stathis Anastasios,
Zucca Emanuele,
Inghirami Giorgio,
Bertoni Francesco
Publication year - 2012
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2012.02321.x
Subject(s) - immunophenotyping , cell , biology , lymphoma , pathology , pathological , natural killer cell , t cell , immunology , cancer research , medicine , genetics , antigen , immune system , cytotoxic t cell , in vitro
Mature (peripheral) T ‐cell and natural killer ( NK )‐cell lymphomas comprise a series of rather different neoplasms. Based on morphologic, immunophenotypic, genetic, and clinical data, the W orld H ealth O rganization classification recognizes more than 20 entities or provisional entities. The variable clinical presentations, the objective recognition and pathological stratification, the difficulties regarding treatment, and the hardly predictable response to therapy indicate that the management of these entities requires novel tools. In contrast to B ‐cell lymphomas or precursor T ‐cell neoplasms, few recurrent translocations have been identified so far in T ‐cell non‐ H odgkin's and NK ‐cell lymphomas. Additionally, some of the entities recognized by the W orld H ealth O rganization classification are very rare and very scarce molecular data are available for T ‐cell lymphomas. Here, we have reviewed published reports focusing on the genetic lesions and gene expression profiling underlying systemic nodal and extranodal non‐cutaneous mature T ‐cell and NK ‐cell lymphomas. We also provide a summary of new agents in clinical development and outline some future directions. ( Cancer Sci , doi: 10.1111/j.1349‐7006.2012.02321.x, 2012)