Open AccessSorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase‐2
Author(s) -
Ara Shihoko,
Kikuchi Tomoki,
Matsumiya Hiroshi,
Kojima Takashi,
Kubo Terufumi,
Ye Rui Carrie,
Sato Akinori,
Kon Shinichiro,
Honma Tomo,
Asakura Kohji,
Hasegawa Tadashi,
Himi Tetsuo,
Sato Noriyuki,
Ichimiya Shingo
Publication year - 2012
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2012.02296.x
Subject(s) - thyroid , thyroid carcinoma , carcinogenesis , immunohistochemistry , cancer research , biology , pathology , thyroid cancer , endocrine system , malignancy , cancer , medicine , endocrinology , hormone
Papillary thyroid carcinoma ( PTC ) is a well‐differentiated endocrine malignant tumor that develops from thyroid follicular epithelium. The tumor represents the most common type of endocrine malignancy; however, its tumorigenesis is not fully elucidated. The aim of this study was to address the functional role of the sorting nexin ( SNX ) family in PTC because of recent experimental evidence suggesting that the SNX family members actively control endocytotic transportation as well as cell fate. Expression profiles of SNX family members of PTC showed a significant quantity of transcripts of SNX 5. Further immunohistochemical analysis with an SNX 5‐specific monoclonal antibody established in this study consistently demonstrated the preferential expression of SNX 5 in PTC (94.2%, 113/120 cases) as indicated by studies on 440 cases of various tumors. In contrast, other major carcinomas originating from the lung (2.6%, 1/38 cases), breast (5.1%, 2/39 cases), and intestine (4.2%, 1/24 cases) scarcely expressed SNX 5. When we investigated models of murine thyroid tumors induced by the administration of carcinogens, high expression of Snx5 was also observed in well‐differentiated thyroid tumors, further implying that the tumorigenesis of the thyroid gland was tightly associated with the abundance of SNX 5/Snx5. Moreover epithelial cells expressing excess SNX 5 showed high levels of Caspase‐2 of an initiator caspase. Collectively these findings suggest that the evaluation of SNX 5 expression would support pathological diagnosis of primary and secondary PTC . ( Cancer Sci 2012; 103: 1356–1362)