Open AccesshOGG1 S er326 C ys polymorphism is associated with risk of bladder cancer in a C hinese population: A case‐control study
Author(s) -
Ma Lan,
Chu Haiyan,
Wang Meilin,
Shi Danni,
Zhong Dongyan,
Li Pu,
Tong Na,
Yin Changjun,
Zhang Zhengdong
Publication year - 2012
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2012.02290.x
Subject(s) - bladder cancer , odds ratio , genotype , medicine , case control study , confidence interval , population , oncology , gastroenterology , cancer , gynecology , biology , genetics , gene , environmental health
Human oxoguanine glycosylase 1 ( hOGG 1) is a DNA repair enzyme, which plays important roles in the base excision repair (BER) pathway. Several studies reported a common polymorphism S er326 C ys (rs1052133) in hOGG1 , which conferred the susceptibility of bladder cancer. We hypothesized that the polymorphism is associated with risk of bladder cancer in a C hinese population. In a case‐control study of 1050 histologically confirmed bladder cancer patients and 1404 age and sex matched healthy controls, we genotyped the hOGG1 S er326 C ys polymorphism using T aq M an technology and assessed its association with bladder cancer risk. We found that the hOGG1 S er/ C ys + S er/ S er genotypes were associated with a significantly increased risk of bladder cancer (adjusted odds ratio [ OR ] = 1.19, 95% confidence interval [ CI ] = 1.01–1.41), compared with the C ys/ C ys genotype. Furthermore, the increased risk was more pronounced among subjects over age 65 years ( OR = 1.31, 95% CI = 1.04–1.66), male subjects ( OR = 1.21, 95% CI = 1.00–1.47), ever smokers ( OR = 1.29, 95% CI = 1.00–1.68) and heavy smokers (>20 pack‐years) ( OR = 1.45, 95% CI = 1.03–2.04). No significant association was observed in the stratification of tumor grade and tumor stage for bladder cancer. In conclusion, our results suggest that hOGG1 S er326 C ys polymorphism may contribute to the susceptibility to bladder cancer in a C hinese population. ( Cancer Sci 2012; 103: 1215–1220)