Open AccessClinicopathological and prognostic impact of human epidermal growth factor receptor type 2 ( HER 2) and hormone receptor expression in uterine papillary serous carcinoma
Author(s) -
Togami Shinichi,
Sasajima Yuko,
Oi Takateru,
Ishikawa Mitsuya,
Onda Takashi,
Ikeda ShunIchi,
Kato Tomoyasu,
Tsuda Hitoshi,
Kasamatsu Takahiro
Publication year - 2012
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2012.02240.x
Subject(s) - univariate analysis , immunohistochemistry , medicine , serous carcinoma , epidermal growth factor receptor , carcinoma , serous fluid , pathological , progesterone receptor , pathology , epidermal growth factor , cancer , receptor , oncology , gastroenterology , multivariate analysis , estrogen receptor , ovarian cancer , breast cancer
Uterine papillary serous carcinoma ( UPSC ) is a rare and aggressive variant of endometrial carcinoma. Little is known about the pathological and biological features of this tumor. Human epidermal growth factor receptor 2 ( HER 2) and hormone receptor ( HR ) expression have an important role in tumor behavior and clinical outcome, but their relevance in UPSC is not clear. In the present study, the immunohistochemical expression of HER 2 and HR was assessed in 27 patients with S tage I disease, 13 with S tage II disease, 25 with S tage III disease, and 6 with S tage IV disease. Correlations between HER 2 and HR expression and the clinicopathological parameters of UPSC were evaluated using C ox's univariate and multivariate analyses. For all patients, the 5‐year recurrence‐free survival ( RFS ) and overall survival ( OS ) rates were 51% and 66%, respectively; in patients with S tage I , II , III and IV disease, the RFS and OS were 67%/81%, 59%/77%, 43%/54% and 0%/0%, respectively. Of all 71 patients, 14% (10/71) were positive for HER 2 and 52% (37/71) were positive for HR . Overexpression of HER 2 was correlated with lower OS ( P = 0.01), whereas HR overexpression was correlated with higher OS ( P = 0.008). In multivariate models, HER 2, HR , and histologic subtype were identified as independent prognostic indicators for RFS ( P = 0.022, P = 0.018, and P = 0.01, respectively), but HR was the only independent factor associated with OS ( P = 0.044). Thus, HER 2 and HR are prognostic variables in UPSC , with HR an independent prognostic factor for OS . ( Cancer Sci 2012; 103: 926–932)