Open AccessBehavior of seeds and soil in the mechanism of metastasis: A deeper understanding
Author(s) -
Mathot Lucy,
Stenninger Johan
Publication year - 2012
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2011.02195.x
Subject(s) - phenomenon , metastasis , mechanism (biology) , homing (biology) , cancer , medicine , neuroscience , biology , epistemology , ecology , philosophy
The so‐called “seed and soil” hypothesis proposed by S tephen P aget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to “selected” sites has been a well‐recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy? ( Cancer Sci 2012; 103: 626–631)