Behavior of seeds and soil in the mechanism of metastasis: A deeper understanding

The so‐called “seed and soil” hypothesis proposed by S tephen P aget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to “selected” sites has been a well‐recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy? ( Cancer Sci 2012; 103: 626–631)