Open AccessDownregulation of GRIM‐19 promotes growth and migration of human glioma cells
Author(s) -
Zhang Yanmin,
Hao Hongbo,
Zhao Shidou,
Liu Qian,
Yuan Qiuhuan,
Ni Shilei,
Wang Fuwu,
Liu Shangming,
Wang Liyan,
Hao Aijun
Publication year - 2011
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2011.02059.x
Subject(s) - glioma , carcinogenesis , downregulation and upregulation , stat3 , stat protein , biology , cancer research , cell growth , activator (genetics) , signal transduction , microbiology and biotechnology , cancer , gene , genetics
It has become increasingly clear that there are notable parallels between normal development and tumorigenesis. Glioma is a classic model that links between tumorigenesis and development. We evaluated the expression of GRIM‐19 , a novel gene essential for normal development, in various grades of gliomas and several human glioma cell lines. We showed that GRIM‐19 mRNA and protein expression were markedly lower in gliomas than in control brain tissues and negatively correlated with the malignancy of gliomas. Downregulation of GRIM‐19 in glioma cells significantly enhanced cell proliferation and migration, whereas overexpression of GRIM‐19 showed the opposite effects. We also showed that the activation of signal transducer and activator of transcription 3 (STAT3) and the expression of many STAT3‐dependent genes were regulated by the expression of GRIM‐19 . In addition, GRIM‐19 exerted its role probably through the non‐STAT3 signaling pathway. Collectively, our data suggest that most gliomas expressed GRIM‐19 at low levels, which may play a major role in tumorigenesis in the brain. ( Cancer Sci 2011; 102: 1991–1999)