Open AccessClinical significance of tumor‐infiltrating FOXP3+ T cells in patients with ocular adnexal mucosa‐associated lymphoid tissue lymphoma
Author(s) -
Kim Ki Hwan,
Kim Tae Min,
Go Heounjeong,
Kim Wook Youn,
Jeon Yoon Kyung,
Lee SeHoon,
Kim DongWan,
In Khwarg Sang,
Kim ChulWoo,
Heo Dae Seog
Publication year - 2011
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2011.02051.x
Subject(s) - foxp3 , lymphoma , medicine , cd8 , chemotherapy , gastroenterology , pathology , immune system , immunology
We evaluated the association between tumor‐infiltrating FOXP3+ T cells and clinical outcomes in patients with ocular adnexal lymphoma of mucosa‐associated lymphoid tissue type (OAML). Pretreatment formalin‐fixed paraffin‐embedded tissues from 42 patients with OAML were stained with 236A/E7 anti‐FOXP3 murine monoclonal antibody as well as CD3, CD4 and CD8 antibodies. The amount of FOXP3+ T cells was numerically quantified using an image analysis program. Front‐line treatments were as follows: combination chemotherapy ( n = 25); radiotherapy ( n = 9); doxycycline ( n = 6); and wait and see ( n = 2). Complete response (CR) was observed in 20 (50%) of 40 evaluable patients. Median progression‐free survival (PFS) was 50 months. A high number of FOXP3+ T cells ( n = 21, ≥180/0.58 mm 2 ) showed a higher CR rate (33% vs 71%, P = 0.013) and tendency towards prolonged PFS (48 vs 67 months, P = 0.110). In the combination chemotherapy group, a high number of FOXP3+ T cells was significantly associated with a higher CR rate (29% vs 82%, P = 0.008) and prolonged PFS (17 vs 79 months, P = 0.003). A high number of tumor‐infiltrating FOXP3+ T cells correlates with a favorable clinical outcome in OAML patients. ( Cancer Sci 2011; 102: 1972–1976)