Open AccessCoexpression of aPKCλ/ι and IL‐6 in prostate cancer tissue correlates with biochemical recurrence
Author(s) -
Ishiguro Hitoshi,
Akimoto Kazunori,
Nagashima Yoji,
Kagawa Eriko,
Sasaki Takeshi,
Sano Jinyu,
Takagawa Ryo,
Fujinami Kiyoshi,
Sasaki Kazunori,
Aoki Ichiro,
Ohno Shigeo,
Kubota Yoshinobu,
Uemura Hiroji
Publication year - 2011
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2011.01972.x
Subject(s) - prostate cancer , proportional hazards model , prostatectomy , biochemical recurrence , prostate , univariate analysis , log rank test , survival analysis , medicine , oncology , cancer , multivariate analysis , univariate , hazard ratio , immunohistochemistry , biology , multivariate statistics , confidence interval , statistics , mathematics
Atypical protein kinase C λ/ι (aPKCλ/ι) and interleukin‐6 (IL‐6) have been implicated in prostate cancer progression, the mechanisms of which have been demonstrated both in vitro and in vivo . However, the clinical significance of the correlation between the expressions of these factors remains to be clarified. In the present study, we report a significant correlation between aPKCλ/ι and IL‐6 proteins in prostate cancer tissue by immunohistochemical staining. We evaluated the association of both proteins by analyzing clinicopathological parameters using chi‐square test, Kaplan–Meier with log–rank test, and a Cox proportional hazard regression model in univariate and multivariate analyses. The results again showed that the expression of aPKCλ/ι and IL‐6 correlates in prostate cancer tissue ( P < 0.001). Atypical protein kinase C λ/ι was also found to correlate with the Gleason score ( P < 0.001) and with biochemical recurrence after prostatectomy ( P = 0.02). Furthermore, aPKCλ/ι correlated with biochemical recurrence in a Kaplan–Meier and log–rank test ( P = 0.01) and Cox analysis ( P = 0.02 in the univariate analysis, P = 0.02 in the multivariate analysis). The coexpression of aPKCλ/ι and IL‐6 also correlated with biochemical recurrence by Kaplan–Meier and log–rank test ( P = 0.005) and Cox analysis ( P = 0.01 in the univariate analysis, P = 0.03 in the multivariate analysis). These results indicate a strong correlation between aPKCλ/ι and IL‐6 in prostate tumors, and that the aPKCλ/ι–IL‐6 axis is a reliable prognostic factor for the biochemical recurrence of this cancer. ( Cancer Sci 2011; 102: 1576–1581)