Open AccessRisk of Japanese carriers of hyperphosphorylated paratarg‐7, the first autosomal‐dominantly inherited risk factor for hematological neoplasms, to develop monoclonal gammopathy of undetermined significance and multiple myeloma
Author(s) -
Grass Sandra,
Iida Shinsuke,
Wikowicz Aleksandra,
Preuss KlausDieter,
Inagaki Atsushi,
Shimizu Kazuyuki,
Ziepert Marita,
Ueda Ryuzo,
Pfreundschuh Michael
Publication year - 2011
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2010.01819.x
Subject(s) - paraproteins , multiple myeloma , monoclonal gammopathy of undetermined significance , medicine , odds ratio , risk factor , incidence (geometry) , population , gastroenterology , antibody , immunology , monoclonal , monoclonal antibody , physics , environmental health , optics
Hyperphosphorylated paratarg‐7 (pP‐7) is a frequent target of paraproteins in German patients with monoclonal gammopathy of undetermined significance (MGUS)/multiple myeloma (MM). The frequency of MGUS/MM is lower in Japan than in Europe. As pP‐7, the first molecularly defined autosomal‐dominant risk factor for any hematological neoplasm, is inherited in a dominant fashion, we determined the incidence of the pP‐7 carrier state in a Japanese population, and compared the frequency of pP‐7‐specific paraproteins and the pP‐7 carrier state in Japanese and German patients with MGUS/MM. Peripheral blood from 111 Japanese patients with MGUS/MM and 278 healthy blood donors was analyzed for the pP‐7 carrier state by isoelectric focusing and for pP‐7‐specific antibodies by ELISA. The Japanese group was compared with 252 German MGUS/MM patients and 200 healthy controls. Five of 111 (4.5%) Japanese and 35/252 (13.9%) German IgA/IgG MGUS/MM patients had a pP‐7‐specific paraprotein ( P = 0.009). The prevalence of healthy pP‐7 carriers in the Japanese study group was 1/278 (0.36%), whereas it was 4/200 in the German group ( P = 0.166). The relative risk for pP‐7 carriers developing MGUS/MM had an odds ratio of 13.1 in the Japanese and 7.9 in the German group. In conclusion, the fraction of pP‐7 carriers with a pP‐7‐specific paraprotein is lower among Japanese than in German patients with MGUS/MM, but pP‐7 carriers in both ethnic groups have a high risk of developing MGUS/MM. ( Cancer Sci 2011; 102: 565–568)