Open AccessMolecular mechanisms of transforming growth factor‐β signaling and disease: The 59th Fujihara International Seminar, 2010
Author(s) -
Miyazono Kohei
Publication year - 2011
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2010.01806.x
Subject(s) - carcinogenesis , smad , transforming growth factor , signal transduction , cancer research , biogenesis , cancer , biology , microbiology and biotechnology , medicine , gene , genetics
The Fujihara International Seminar series is supported by the Fujihara Foundation for Science, for the purpose of organizing seminars for basic and applied science, including medical science, physics, chemistry, engineering, mathematics, geology, and biology. The 59th Fujihara International Seminar was held on July 14–17, 2010 at Tomakomai, Hokkaido, Japan, focusing on molecular mechanisms of transforming growth factor (TGF)‐β signaling and disease. Recent findings on mechanisms of TGF‐β signaling, the roles of TGF‐β signaling in carcinogenesis and progression of tumors, and possible strategies of TGF‐β‐based treatment of cancer were discussed at the seminar. In particular, novel mechanisms of regulation of Smad signaling, the differential roles of Smad proteins in carcinogenesis, function of Smads in regulation of microRNA biogenesis, and treatment of cancer stem cells by targeting the TGF‐β signaling pathways were discussed. ( Cancer Sci 2011; 102: 1242–1244)