Open AccessFirst‐line therapy with doxycycline in ocular adnexal mucosa‐associated lymphoid tissue lymphoma: A retrospective analysis of clinical predictors
Author(s) -
Kim Tae Min,
Kim Ki Hwan,
Lee Min Joung,
Jeon Yoon Kyung,
Lee SeHoon,
Kim DongWan,
Kim Chul Woo,
Kim Il Han,
Khwarg Sang In,
Heo Dae Seog
Publication year - 2010
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2010.01502.x
Subject(s) - neutrophilia , lymphocytosis , medicine , gastroenterology , doxycycline , absolute neutrophil count , lymphoma , retrospective cohort study , confidence interval , odds ratio , chemotherapy , antibiotics , neutropenia , microbiology and biotechnology , biology
This retrospective study was launched to evaluate the efficacy of doxycycline and to find independent predictors of a clinical response in patients with ocular adnexal lymphoma of mucosa‐associated lymphoid tissue (OAML). Thirty‐eight patients with newly diagnosed, localized OAML received doxycycline for 3 weeks (12 patients) or 6 weeks (26 patients). Clinical factors including absolute lymphocyte count (ALC) and neutrophil count (ANC) were compared between responders and non‐responders. After a median follow‐up of 26.4 months, doxycycline resulted in an overall response rate of 47% and a 3‐year time‐to‐treatment failure (TTF) rate of 84%. Patients treated with doxycycline for 6 weeks versus 3 weeks tended to have a higher response rate (54% vs 33%). Absolute lymphocytosis (ALC > 3.01 × 10 9 /L) and absolute neutrophilia (ANC > 1.92 × 10 9 /L) were defined based on the median value of each count. Patients with (19 patients) versus without absolute lymphocytosis had significantly shorter 2‐year TTF (70% vs 100%, P = 0.021) and a lower response rate (32% vs 63%, P = 0.051). Absolute lymphocytosis (odds ratio [OR] = 4.7; 95% confidence interval [CI], 1.1–20.8; P = 0.043) and non‐conjunctival tumor (OR = 11.8; 95% CI, 1.1–122.5; P = 0.038) were negative predictors for response by multivariate analysis. Front‐line doxycycline is effective particularly in localized OAML patients without absolute lymphocytosis but with conjunctival involvement. ( Cancer Sci 2010; 101: 1199–1203)