Open AccessAltered phenotype of lymphatic endothelial cells induced by highly metastatic OTSCC cells contributed to the lymphatic metastasis of OTSCC cells
Author(s) -
Zhuang Zhang,
Jian Pan,
Longjiang Li,
Bo Han,
Wenlin Xiao
Publication year - 2010
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2009.01444.x
Subject(s) - lymphatic endothelium , lymphatic system , cancer cell , cancer , chemokine , cell , metastasis , pathology , cancer research , biology , phenotype , medicine , immunology , inflammation , gene , genetics , biochemistry
( Cancer Sci 2010; 101: 686–692) The lymphatic endothelial cell (LEC) is an interactive surface for cancer cells. This article aims to explore cancer cell‐induced changes of LEC, and study the tumor–lymphatic endothelium interaction. Here, LECs were co‐cultured with highly and poorly metastatic tongue cancer cells. The differences in biologic behaviors and gene expression profiles between them were examined. The results showed that LECs induced by highly metastatic cancer cells displayed abnormal biologic behaviors, and could secrete chemokines to promote the migration of cancer cells. Therefore, biologic properties and functional status of LECs in oral tongue squamous cell carcinoma (OTSCC) might be a positive factor in lymphatic dissemination.