Open AccessPDCD4 inhibits the malignant phenotype of ovarian cancer cells
Author(s) -
Wei ZengTao,
Zhang Xia,
Wang XiaoYan,
Gao Fei,
Zhou ChengJun,
Zhu FaLiang,
Wang Qun,
Gao Qi,
Ma ChunHong,
Sun WenSheng,
Fu QingZhao,
Chen YouHai H.,
Zhang LiNing
Publication year - 2009
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2009.01210.x
Subject(s) - ovarian cancer , cancer research , phenotype , ovarian carcinoma , cancer , activator (genetics) , apoptosis , cancer cell , suppressor , biology , cell growth , programmed cell death , gene , genetics
Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor that can inhibit activator protein (AP)‐1 activation and protein translation. Our previous studies indicate that lost or reduced PDCD4 expression is associated with the progression of ovarian carcinoma. However, direct evidence that PDCD4 inhibits malignant phenotype of human cancer cells is limited. In the present study, we found that PDCD4 expression in ovarian cancer cell lines (SKOV3, 3AO, and CAOV3) inhibited significantly their proliferation and cell cycle progression, and induced apoptosis. More importantly, up‐regulation of PDCD4 expression decreased the colony‐forming capacity of ovarian cancer cells in vitro and tumorigenic capacity in mice. These results demonstrate that PDCD4 can suppress the malignant phenotype of ovarian cancer cells, and may represent a novel therapeutic target for the treatment of ovarian cancer. ( Cancer Sci 2009)