Open AccessInterferon regulatory factor family of transcription factors and regulation of oncogenesis
Author(s) -
Takaoka Akinori,
Tamura Tomohiko,
Taniguchi Tadatsugu
Publication year - 2008
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2007.00720.x
Subject(s) - interferon regulatory factors , transcription factor , biology , irf8 , interferon , carcinogenesis , irf1 , context (archaeology) , innate immune system , immunology , gene , immune system , genetics , paleontology
A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)‐α/β system. The IRF family has now expanded to nine members, and gene‐disruption studies have revealed the critical involvement of these members in multiple facets of host defense systems, such as innate and adaptive immune responses and tumor suppression. In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis. ( Cancer Sci 2008; 99: 467–478)