Open AccessPrognostic implications of the nuclear localization of Y‐box‐binding protein‐1 and CXCR4 expression in ovarian cancer: Their correlation with activated Akt, LRP/MVP and P‐glycoprotein expression
Author(s) -
Oda Yoshinao,
Ohishi Yoshihiro,
Basaki Yuji,
Kobayashi Hiroaki,
Hirakawa Toshio,
Wake Norio,
Ono Mayumi,
Nishio Kazuto,
Kuwano Michihiko,
Tsuneyoshi Masazumi
Publication year - 2007
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2007.00492.x
Subject(s) - cxcr4 , ovarian cancer , protein expression , expression (computer science) , cancer research , correlation , protein kinase b , cancer , glycoprotein , biology , nuclear protein , oncology , medicine , microbiology and biotechnology , signal transduction , gene , receptor , genetics , transcription factor , computer science , chemokine , geometry , mathematics , programming language
The nuclear localization of Y‐box‐binding protein‐1 (YB‐1) is known to be a poor prognostic factor in several human malignancies, including ovarian carcinoma. Following on from our basic study dealing with microarray analyses of YB‐1‐associated gene expression in ovarian cancer cells, we examined whether nuclear localization of YB‐1 is associated with the expression of CXCR4, a vault protein named lung resistance‐related vault protein (LRP/MVP), phosphorylated Akt (p‐Akt) or P‐glycoprotein (P‐gp) in human ovarian carcinoma. Fifty‐three surgically resected ovarian carcinomas treated with paclitaxel and carboplatin were examined immunohistochemically for nuclear YB‐1 expression and intrinsic expression of p‐Akt, P‐gp, LRP/MVP and CXCR4. Nuclear expression of YB‐1 demonstrated significant correlation with p‐Akt, P‐gp and LRP expression, but no relationship with CXCR4 expression. By multivariate analysis, only YB‐1 nuclear expression and CXCR4 expression were independent prognostic factors with regard to overall survival. These results indicate that YB‐1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma. ( Cancer Sci 2007; 98: 1020–1026)