Open AccessPlausible linkage of hypoxia inducible factor‐1α in uterine cervical cancer
Author(s) -
Fujimoto Jiro,
Alam Syed Mahfuzul,
Jahan Israt,
Sato Eriko,
Toyoki Hiroshi,
Hong Bao Li,
Sakaguchi Hideki,
Tamaya Teruhiko
Publication year - 2006
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2006.00262.x
Subject(s) - angiogenesis , cervical cancer , hypoxia (environmental) , thymidine phosphorylase , medicine , hypoxia inducible factors , hif1a , neovascularization , metastasis , oncology , cancer research , cancer , biology , gene , chemistry , biochemistry , organic chemistry , oxygen
Angiogenesis is essential for the development, growth and advancement of solid tumors. Angiogenesis is induced by hypoxia with angiogenic transcription factor hypoxia inducible factors (HIF). This prompted us to study the clinical implications of HIF relative to angiogenesis in uterine cervical cancers. Although there was no significant difference in HIF‐1α histoscores and mRNA levels according to histopathological type or lymph node metastasis, HIF‐1α histoscores and mRNA levels increased significantly with advancing cancer stages. The prognosis of 30 patients with high HIF‐1α in uterine cervical cancers was poor (73% survival), whereas the 24‐month survival rate of the other 30 patients with low HIF‐1α was 93%. HIF‐1α histoscores and mRNA levels were correlated with the levels of the angiogenic factors thymidine phosphorylase and interleukin‐8, and HIF‐1α might be linked with these factors in cervical cancer tissue. HIF‐1α is a candidate for prognostic indicator as an angiogenic mediator in uterine cervical cancer. ( Cancer Sci 2006; 97: 861–867)