Open AccessERK MAP kinase in G 1 cell cycle progression and cancer
Author(s) -
Torii Satoru,
Yamamoto Takuya,
Tsuchiya Yoshiki,
Nishida Eisuke
Publication year - 2006
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2006.00244.x
Subject(s) - mapk/erk pathway , microbiology and biotechnology , signal transduction , kinase , cell cycle , protein kinase a , cell growth , scaffold protein , mitogen activated protein kinase , biology , cell signaling , cell fate determination , cell , cancer research , biochemistry , transcription factor , gene
The extracellular‐signal‐regulated kinase (ERK) mitogen‐activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling‐related proteins, such as scaffold proteins and inhibitors. These proteins modulate ERK signaling and thereby could give variations in ERK signaling outputs that regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle progression from G 0 /G 1 to S phase and cancer. ( Cancer Sci 2006; 97: 697–702)