Open AccessAssociation of the OGG1 ‐Ser326Cys polymorphism with lung adenocarcinoma risk
Author(s) -
Kohno Takashi,
Kunitoh Hideo,
Toyama Kaoru,
Yamamoto Seiichiro,
Kuchiba Aya,
Saito Daizo,
Yanagitani Noriko,
Ishihara Shinichi,
Saito Ryusei,
Yokota Jun
Publication year - 2006
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2006.00240.x
Subject(s) - odds ratio , allele , lung cancer , medicine , adenocarcinoma , oncology , adenocarcinoma of the lung , confidence interval , gastroenterology , case control study , population , lung , biology , genetics , cancer , gene , environmental health
Adenocarcinoma (ADC) is the most frequent histological type of lung cancer and comprises the majority of lung cancers in non‐smokers. Thus, genetic factors responsible for ADC susceptibility need to be determined to establish efficient ways of preventing the disease. The OGG1 gene, encoding a glycosylase for 8‐hydroxyguanine, an oxidatively damaged promutagenic base, has the polymorphism Ser326Cys, and OGG1‐326Cys protein was indicated to have a lower ability to prevent mutagenesis than the OGG1‐326Ser protein. Case‐control studies to date suggest that the OGG1 ‐326Cys allele is associated with a higher risk for several types of cancers, including overall lung cancer. However, the contribution of this polymorphism to lung ADC risk is unclear. In the present study, the OGG1 ‐Ser326Cys polymorphism was assessed for association with lung ADC risk using a case‐control study of a Japanese population consisting of 1097 cases and 394 controls. Odds ratios (OR) of the 326Cys allele carriers increased in a dose‐dependent manner with allele number ( P for the trend test = 0.04). The OR of homozygotes for the 326Cys allele was increased significantly when homozygotes for the 326Ser allele were used as a reference (OR = 1.5, 95% confidence interval [CI] = 1.0–2.1, P = 0.04). Furthermore, the overall OR for lung ADC of the Cys/Cys homozygotes out of a total of 1925 ADC patients and 3449 controls from six case‐control studies reported up to the present were 1.43 (95% CI = 1.11–1.84, P = 0.0045). These results indicate that OGG1 ‐326Cys functions as a risk allele for lung ADC development. ( Cancer Sci 2006; 97: 724–728)