Open AccessThe D4Mit12 locus on mouse chromosome 4 provides susceptibility to both γ‐ray‐induced and N‐methyl‐N‐nitrosourea‐induced thymic lymphomas
Author(s) -
Sato Hiroki,
Tamura Yasushi,
Ochiai Yukie,
Kodama Yasumitsu,
Hatakeyama Katsuyoshi,
Niwa Ohtsura,
Kominami Ryo
Publication year - 2003
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2003.tb01500.x
Subject(s) - congenic , locus (genetics) , biology , allele , penetrance , genetics , gene , genetic linkage , chromosome 17 (human) , microbiology and biotechnology , chromosome , cancer research , phenotype
Low‐penetrance genes control different susceptibilities to γ‐ray‐induced thymic lymphomas in mouse strains. Our previous genetic analyses with backcross mice between BALB/c and MSM strains and congenic lines localized one such gene near the D4Mit12 locus on chromosome 4. N‐Methyl‐N‐nitrosourea (MNU) is a guanine base‐alkylating agent and differs from γ‐radiation in its mechanism of mutagenic action. Accordingly, in this study, we examined whether or not the locus also provides susceptibility to MNU‐induced thymic lymphomas using 84 offsprings derived from congenic mice for D4Mit12 . Association analysis provided a suggestive linkage at D4Mit12 (P=0.0075) and the linkage was sustained by the peak of likelihood ratio statistical values being at the same position as that for the γ‐ray‐induced lymphomas. The results strongly suggest that the BALB/c allele near D4Mit12 is associated with susceptibility to lymphomas induced by two carcinogenic agents having different mechanisms of mutagenic action.