Open AccessThe prognosis in spindle‐cell sarcoma depends on the expression of cyclin‐dependent kinase inhibitor p27 Kip1 and cyclin E
Author(s) -
Goto Yoshinari,
Kawauchi Shigeto,
Lhara Koichiro,
Ikemoto Kenzo,
Ohi Ritsuko,
Kawai Shinya,
Sasaki Kohsuke
Publication year - 2003
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2003.tb01456.x
Subject(s) - cyclin , biopsy , cell cycle , cancer research , sarcoma , cyclin e , biology , immunohistochemistry , cyclin d1 , pathology , cell , medicine , genetics
The aim of the present study was to examine the prognostic significance of p27 Kip1 and cyclin E expression in patients with spindle‐cell soft tissue sarcomas. In 46 cases of spindle‐cell sarcoma including 17 pre‐operative biopsy materials, the expression of p27 Kip1 and cyclin e was immunohistochemically examined. The expression of p27 Kip1 decreased in the nuclei of metastatic primary tumor cells (stage IV), whereas the expression of cyclin E increased in those lesions. On univariate analysis, when the expression of p27 Kip1 and cyclin E was analyzed together, patients with spindle‐cell sarcoma exhibiting low expression of p27 Kip1 and high expression of cyclin E showed lower distant‐metastasis‐free survival (DMFS) and overall survival (OS) than those with other combinations of the two parameters (both P <0.0001). Multivariate analysis revealed that patients with low p27 Kip1 and high cyclin E expression also showed a decrease in DMFS ( P =0.0007, relative risk=21.3) and OS (P=0.005, relative risk=20.8). These results suggest that the combination analysis of p27 Kip1 and cyclin E expression even in biopsy specimens allows the prediction of the clinical behavior of spindle‐cell sarcoma. (Cancer Sci 2003; 94: 412–417)