Open AccessAntitumor Effect of the Idiotypic Cascade Induced by an Antibody Encapsulated in Poly( d, l ‐lactide‐ co ‐glycolide) Microspheres
Author(s) -
Ma Jie,
Luo Dong,
Qi Weimin,
Cao Liren
Publication year - 2001
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.2001.tb01066.x
Subject(s) - immunogenicity , antibody , idiotopes , monoclonal antibody , antigen , microsphere , chemistry , cancer , breast cancer , medicine , microbiology and biotechnology , cancer research , immunology , monoclonal , biology , chemical engineering , engineering
A major difficulty encountered during development of antibody vaccines is their weak immunogenicity. In this study, a monoclonal antibody CS20.5 to human breast cancer antigen CA15.3 was coencapsulated in poly( d, l ‐lactide‐ co ‐glycolide) microspheres with monophosphoryl lipid A. The antitumor effect of this formulation was investigated in a murine model. The induced Ab2 biologically mimics antigen as it competed with CA15.3 for the same idiotope on Abl. Ab3 induction was also observed. After five sequential administrations of encapsulated antibody, mice showed statistically significant tumor regression. These results indicate that this formulation may serve as a potential treatment for breast cancer.