Open AccessAllelic Loss of the Region of Chromosome 1p35‐pter Is Associated with Progression of Human Gastric Carcinoma
Author(s) -
Igarashi Jun,
Nimura Yoshinori,
Fujimori Minoru,
Mihara Motohiro,
Adachi Wataru,
Kageyama Hajime,
Nakagawara Akira
Publication year - 2000
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.2000.tb01016.x
Subject(s) - loss of heterozygosity , biology , chromosome , allele , microsatellite , genetics , tumor suppressor gene , microbiology and biotechnology , gene , carcinogenesis
In order to identify the region on distal chromosome 1p that is thought to include one or more tumor suppressor genes for gastric carcinoma, 39 gastric carcinomas were examined for allelic loss using 11 polymorphic microsatellite markers and 1 marker of single strand conformation polymorphism. Loss of heterozygosity (LOH) was found in 18 (46%) of 39 informative patients. The regions with high frequency of loss of heterozygosity were the loci at D1S548 (6/17; 35.3%) and D1S2843 (7/20; 35%), and we found three commonly deleted regions on chromosome 1p35‐pter. The frequency of allelic loss in the region of chromosome 1p35‐pter was significantly associated with advanced‐stage gastric carcinoma, but not with early‐stage tumor or with the histology. These results suggest that allelic loss at chromosome 1p35‐pter may play a role in the progression of gastric carcinoma.