Open AccessSignificance of Thymidine Phosphorylase/Platelet‐derived Endothelial Cell Growth Factor in Carcinoma of the Papilla of Vater
Author(s) -
Zhao Bin,
Kimura Wataru,
Futakawa Noriaki,
Abe Hideki,
Kitayama Joji,
Nagawa Hirokazu,
Makuuchi Masatoshi
Publication year - 2000
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.2000.tb00949.x
Subject(s) - thymidine phosphorylase , microvessel , major duodenal papilla , pathology , immunohistochemistry , neovascularization , carcinoma , tumor progression , medicine , metastasis , biology , angiogenesis , cancer research , cancer
The expression of thymidine phosphorylase (TP) in carcinoma of the papilla of Vater was studied to clarify its significance in tumor progression and in determining prognosis. Fifty‐nine cases of surgically resected carcinoma of the papilla of Vater were studied. Immunohistochemical staining was performed to evaluate the expression of TP, microvessel count and p53 overexpression. TP expression was demonstrated in tumor cells in 62.7% (37/59) of the cases. A higher frequency of regional lymph node metastasis was found in TP‐positive tumors than in TP‐negative tumors ( P =0.006). TP‐positive tumors were more advanced than TP‐negative tumors with regard to clinical stage ( P =0.035). TP‐positive tumors had significantly higher microvessel density (27.6±10.1) than TP‐negative tumors (20.4±10.0, P =0.01). Moreover, TP expression was significantly correlated with a poor prognosis ( P =0.02). These suggest that in carcinoma of the papilla of Vater, TP production by tumor cells is correlated with tumor progression through its regulatory effect on neovascularization.