Open AccessMitochondrial Lipid Peroxides and Antioxidant Enzymes in Colorectal Adenocarcinoma Tissues
Author(s) -
Kanbağh Öznur,
Özdemirler Gül,
Bulut Türker,
Yamaner Sümer,
AykaçToker Gülçin,
Uysal Müjdat
Publication year - 2000
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.2000.tb00912.x
Subject(s) - lipid peroxide , glutathione peroxidase , superoxide dismutase , lipid peroxidation , glutathione , antioxidant , glutathione reductase , mitochondrion , necrosis , chemistry , pathology , colorectal cancer , biochemistry , biology , enzyme , medicine , cancer
Lipid peroxide levels and superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and glutathione transferase (GST) activities were investigated in mitochondrial fractions obtained from tumorous and nontumorous colorectal tissues of fourteen patients with colon and rectum cancer. Histopathological evaluations, including type, stage, necrosis and lymphocyte infiltration were also performed for each patient. The activities of SOD, GSH‐Px and GST were increased significantly, but lipid peroxide levels remained unchanged in mitochondria obtained from tumors compared to adjacent normal tissues of subjects with colorectal cancer. When the patients were grouped according to their histopathological evaluation, such as type, stage, necrosis and lymphocyte infiltration, no relationship was observed between the histopathological results and the mitochondrial lipid peroxidation or antioxidant enzyme activities.