Open AccessAn Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
Author(s) -
Nishimura Goshi,
Yanoma Shunsuke,
Satake Kenichi,
Ikeda Yoichi,
Taguchi Takahide,
Nakamura Yoshiyasu,
Hirose Fumikazu,
Tsukuda Mamoru
Publication year - 2000
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.2000.tb00905.x
Subject(s) - probucol , medicine , carcinoma , combination therapy , angiogenesis , transplantation , head and neck , head and neck cancer , pharmacology , oncology , cancer research , surgery , cancer , cholesterol
An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)‐2 inhibitor, probucol, an antioxidant, and S‐1, an oral pro‐drug of 5‐fluorouracil (5‐FU), or combinations of two of them. The combined administration of tiracoxib with probucol significantly inhibited the tumor growth. The angiogenesis in this group was markedly reduced. Tiracoxib and probucol did not affect the intratumoral concentration of 5‐FU when coadministered with S‐1. The combined use of tiracoxib and probucol is thus a candidate for use in maintenance therapy after the primary therapy for patients with advanced head and neck carcinoma.