Open AccessA Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
Author(s) -
Okimoto Kazuo,
Kouchi Mami,
Kikawa Emi,
Toyosawa Kaoru,
Koujitani Takatoshi,
Tanaka Kohji,
Matsuoka Nobuo,
Sakurai Junko,
Hino Okio
Publication year - 2000
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.2000.tb00890.x
Subject(s) - carcinogenesis , renal cell carcinoma , southern blot , biology , mendelian inheritance , cell , pathology , carcinoma , gene , medicine , endocrinology , genetics
A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague‐Dawley strain in Japan, and named the “Nihon'’rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL , and c‐Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.