Open AccessRisk of Breast Cancer in Japanese Women with Benign Breast Disease
Author(s) -
Minami Yuko,
Ohuchi Noriaki,
Taeda Yoshinori,
Takano Akira,
Fukao Akira,
Satomi Susumu,
Hisamichi Shigeru
Publication year - 1999
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1999.tb00789.x
Subject(s) - breast cancer , medicine , breast disease , mammary gland , disease , oncology , cancer , gynecology
To investigate the risk of breast cancer development in women with benign breast disease (BBD), 387 screen‐detected BBD women and 1,489 normal women, taken from participants in the breast cancer screening program during 1978–1986, were followed through 1991. While 2,811 person‐years in the BBD group and 11,018 person‐years in the normal group were accumulated, 5 women in the BBD group and 6 women in the normal group developed breast cancer. Using the Mantel‐Haenszel method, relative risks (RR) were estimated for all women with BBD and women in some BBD types. Significantly elevated risk of breast cancer was observed in all women with BBD (RR=3.26, 95% confidence interval (CI) 1.08−9.83). Women with proliferative BBD were at high risk of breast cancer (RR=8.48, 95%CI 2.99−24.10), but no increased risk was observed for women with non‐proliferative BBD (RR=0.93, 95%CI 0.11−7.66). These results are consistent with those in high‐risk countries for breast cancer. In the management of women with BBD, histopathological diagnosis of the breast lesion is essential and women with proliferative BBD should be followed up carefully.