Open AccessInhibitory Effects of Nabumetone, a Cyclooxygenase‐2 Inhibitor, and Esculetin, a Lipoxygenase Inhibitor, on N ‐Methyl‐ N ‐nitrosourea‐induced Mammary Carcinogenesis in Rats
Author(s) -
Matsunaga Kengo,
Yoshimi Naoki,
Yamada Yasuhiro,
Shimizu Masahito,
Kawabata Kunihiro,
Ozawa Yuki,
Hara Akira,
Mori Hideki
Publication year - 1998
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1998.tb03289.x
Subject(s) - nabumetone , cyclooxygenase , anticarcinogen , lipoxygenase , carcinogenesis , chemistry , medicine , arachidonate 5 lipoxygenase , subcutaneous injection , endocrinology , nitrosourea , pharmacology , biochemistry , enzyme , arachidonic acid , cancer , chemotherapy , nonsteroidal
We investigated the modifying effects of nabumetone, a relatively selective cyclooxygenase‐2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N ‐methyl‐ N ‐nitrosourea(MNU)‐induced mammary carcinogenesis in female Sprague‐Dawley rats. A total of 124 rats, 6 weeks old, were divided into 6 groups. At 50 days of age, groups 1, 2, and 3 were treated with MNU (50 mg/kg body weight) by subcutaneous injection. From the age of 8 weeks, groups 2 and 4 were given 0.03% nabumetone in the diet and groups 3 and 5 were given 0.03% esculetin in the diet. All rats were necropsied at the termination (25 weeks after the start of experiment). The incidence and multiplicity of neoplasms in group 2 were significantly smaller than those in group 1 ( P <0.005 and P <0.001, respectively). The incidence of neoplasms in group 3 was also significantly smaller than that in group 1 ( P <0.05). These results indicate that the intake of nabumetone or esculetin during the time corresponding to the post initiation phase has a chemopreventive effect on MNU‐induced mammary carcinogenesis in rats.