Open AccessLung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
Author(s) -
Inoue Masaaki,
Osaki Toshihiro,
Noguchi Masayuki,
Hirohashi Setsuo,
Yasumoto Kosei,
Kasai Hiroshi
Publication year - 1998
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1998.tb03272.x
Subject(s) - adenocarcinoma , lung cancer , lung , adenocarcinoma of the lung , pathology , peripheral , medicine , cancer , basal cell , squamous carcinoma , respiratory disease , carcinoma
The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients ( n =70) and non‐cancer patient controls ( n =15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non‐cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non‐adenocarcinoma).