Open AccessGenetic Alterations of Mixed Hyperplastic Adenomatous Polyps in the Colon and Rectum
Author(s) -
Uchida Hiroyuki,
Ando Hiroshi,
Maruyama Keiji,
Kobayashi Hiroshi,
Toda Hiroshi,
Ogawa Hiroshi,
Ozawa Takachika,
Matsuda Yasuhide,
Sugimura Haruhiko,
Kanno Takashi,
Baba Shozo
Publication year - 1998
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1998.tb00562.x
Subject(s) - hyperplastic polyp , rectum , adenomatous polyps , mutation , hyperplasia , adenoma , intestinal polyp , germline mutation , adenomatous polyposis coli , somatic cell , carcinoma , pathology , gastroenterology , medicine , cancer research , biology , colorectal cancer , cancer , colonoscopy , genetics , gene
Some mixed hyperplastic adenomatous polyps (MHAPs) contain dysplastic lesions or even carcinomas. These polyps are considered to be different from ordinary hyperplastic polyps and may have a preneoplastic potential. We investigated APC and K‐ ras mutations in MHAPs of the colon and rectum, and also in colorectal adenomas and hyperplastic polyps to identify molecular differences between MHAPs, adenomas and hyperplastic polyps, using direct sequencing of mutation cluster regions (MCR) in APC and K‐ ras . No APC mutations were identified in 12 MHAPs and 8 hyperplastic polyps, whereas 10 of 27 (37.0%) adenomas showed somatic mutations. K‐ ras mutations were identified in one of 12 (8.3%) MHAPs, one of 8 (12.5%) hyperplastic polyps, and 10 of 27 (37.0%) adenomas. p53 mutation was found in a carcinoma arising in an MHAP. Mutations other than APC mutations may play a role in the development of MHAPs.