Open AccessTransgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
Author(s) -
Matsuda Junichi,
Suzuki Misao,
Nozaki Chikateru,
Shinya Noriko,
Tashiro Kayo,
Mizuno Kyousuke,
Uchinuno Youichi,
Yamamura Kenichi
Publication year - 1998
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1998.tb00543.x
Subject(s) - complementary dna , virology , genetically modified mouse , hepatitis c virus , transgene , biology , virus , antibody , hepatitis , microbiology and biotechnology , hepatitis c , gene , immunology , genetics
Hepatitis C virus (HCV), a major causative agent of post transfusion non‐A, non‐B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full‐length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver‐specific expression. In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV‐related antibody was detected in the serum.