Open AccessInduction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
Author(s) -
Takegawa Kiyoshi,
Mitsumori Kunitoshi,
Onodera Hiroshi,
Yasuhara Kazuo,
Kitaura Keisuke,
Shimo Takeo,
Takahashi Michihito
Publication year - 1998
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1998.tb00536.x
Subject(s) - squamous metaplasia , pathology , metaplasia , atrophy , epithelium , carcinogen , cell growth , salivary gland , medicine , endocrinology , biology , chemistry , genetics
In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism.