Open AccessThe PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
Author(s) -
Yoshinaga Kousuke,
Sasano Hironobu,
Furukawa Toru,
Yamakawa Hiromitsu,
Yuki Michihiro,
Sato Shinji,
Yajima Akira,
Horii Akira
Publication year - 1998
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1998.tb00485.x
Subject(s) - pten , carcinogenesis , microsatellite instability , cancer research , pathogenesis , gene , mutation , hyperplasia , endometrial hyperplasia , endometrial cancer , biology , pathology , microbiology and biotechnology , apoptosis , medicine , genetics , cancer , microsatellite , pi3k/akt/mtor pathway , allele
To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGFβRII, IGFIIR , and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX , and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX , and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.