Open AccessInhibition of Azoxymethane‐initiated Colon Tumor by Bovine Lactoferrin Administration in F344 Rats
Author(s) -
Sekine Kazunori,
Watanabe Emiko,
Nakamura Joe,
Takasuka Nobuo,
Kim Dae Joong,
Asamoto Makoto,
Krutovskikh Vladimir,
BabaToriyama Hiroyasu,
Ota Tomonori,
Moore Malcolm A.,
Masuda Mitsuharu,
Sugimoto Hajime,
Nishino Hoyoku,
Kakizoe Tadao,
Tsuda Hiroyuki
Publication year - 1997
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1997.tb00413.x
Subject(s) - azoxymethane , lactoferrin , medicine , endocrinology , chemistry , colorectal cancer , biochemistry , cancer
The influence of bovine lactoferrin (bLF) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). Following three weekly injections of AOM, the animals received 2 or 0.2% bLF for 36 weeks. No effects indicative of toxicity were noted, but significant reduction in both the incidence and number of adenocarcinomas of the large intestine was observed with both doses. Thus, the incidences of adenocarcinomas in the groups receiving 2% and 0.2% bLF were 15% and 25%, respectively, in contrast to the 57.5% control value (P < 0.01 and P<0.05, respectively). The results indicate that bLF might find application for chemoprevention of colon cancer.